REV1

Domain

The C-terminal domain is necessary for protein interactions.

Function

Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.

Sequence Similarities

Belongs to the DNA polymerase type-Y family.

Tissue Specificity

Ubiquitous.

Cellular localization

• Nucleus

Alternative names

REV1L, REV1, DNA repair protein REV1, Alpha integrin-binding protein 80, Rev1-like terminal deoxycytidyl transferase, AIBP80

Database links

swissprot:Q9UBZ9 genbank:NP_057400 omim:606134 entrezGene:51455