REV3L
Domain
Its C-terminal part could serve as the catalytic domain during nucleotide polymerization, while its N-terminal part could provide sites for protein-protein interactions with other factors during translesion DNA synthesis.
The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.
Function
Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.
Sequence Similarities
Belongs to the DNA polymerase type-B family.
Tissue Specificity
Ubiquitously expressed.
Cellular localization
- Nucleus
Alternative names
POLZ, REV3, REV3L, DNA polymerase zeta catalytic subunit, Protein reversionless 3-like, REV3-like, hREV3