RGM domain family member B
Function
Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.
Post-translational modifications
GPI-anchored.
Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds.
Sequence Similarities
Belongs to the repulsive guidance molecule (RGM) family.
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
- Membrane raft
Alternative names
Repulsive guidance molecule B, DRG11-responsive axonal guidance and outgrowth of neurite, DRAGON, RGMB