rgpA
Function
Thiol protease. Acts synergistically with RgpB to catalyze the maturation of fimbrial subunits, such as FimA (By similarity). Its proteolytic activity is a major factor in both periodontal tissue destruction and in evasion of host defense mechanisms (Probable).
Sequence Similarities
Belongs to the peptidase C25 family.
Cellular localization
- Secreted
Alternative names
rgp1, rgpA, Gingipain R1, Arg-gingipain, Gingipain 1, RGP-1