RGR
Function
Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism.
Involvement in disease
Retinitis pigmentosa 44
RP44
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Covalently binds all-trans- and 11-cis-retinal.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
Tissue Specificity
Preferentially expressed at high levels in the retinal pigment epithelium (RPE) and Mueller cells of the neural retina.
Cellular localization
- Membrane
- Multi-pass membrane protein
Alternative names
RPE-retinal G protein-coupled receptor, RGR