RGS10

Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:10608901, PubMed:11443111, PubMed:18434541, PubMed:8774883, PubMed:9353196). Modulates the activity of potassium channels that are activated in response to CHRM2 signaling (PubMed:11443111). Activity on GNAZ is inhibited by palmitoylation of the G-protein (PubMed:9353196).

• Isoform 1
• Cytoplasm
• Cytosol
• Nucleus
• Forskolin treatment promotes phosphorylation and translocation to the nucleus.
• Nucleus

Regulator of G-protein signaling 10, RGS10

• entrezGene:6001
• omim:602856
• swissprot:O43665

Proteins

Neuroscience

21210Da