RGS16
Function
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11602604, PubMed:18434541). Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals (By similarity).
Post-translational modifications
Palmitoylated on Cys-2 and/or Cys-12.
Phosphorylated. Phosphorylation at Tyr-168 by EGFR enhances GTPase accelerating (GAP) activity toward GNAI1.
Tissue Specificity
Abundantly expressed in retina with lower levels of expression in most other tissues.
Cellular localization
- Membrane
- Lipid-anchor
Alternative names
RGSR, RGS16, Regulator of G-protein signaling 16, A28-RGS14P, Retinal-specific RGS, Retinally abundant regulator of G-protein signaling, RGS-r, hRGS-r