RGS2
Function
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320).
Post-translational modifications
Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.
Tissue Specificity
Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).
Cellular localization
- Isoform 1
- Cell membrane
- Cytoplasm
- Nucleus
- Nucleolus
- Isoform 2
- Cell membrane
- Cytoplasm
- Nucleus
- Nucleolus
- Isoform 3
- Cell membrane
- Cytoplasm
- Nucleus
- Nucleolus
- Isoform 4
- Cell membrane
- Mitochondrion
Alternative names
G0S8, GIG31, RGS2, Regulator of G-protein signaling 2, Cell growth-inhibiting gene 31 protein, G0/G1 switch regulatory protein 8