RGS20
Function
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).
Post-translational modifications
Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity).
N- and O-glycosylated in synapsomal membranes.
Serine phosphorylated in synapsomal membranes.
Sumoylated with SUMO1 and SUMO2 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits (By similarity).
Tissue Specificity
Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe.
Cellular localization
- Membrane
- Lipid-anchor
- Nucleus
- Cytoplasm
- Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation.
Alternative names
RGSZ1, ZGAP1, RGS20, Regulator of G-protein signaling 20, Gz-selective GTPase-activating protein, Regulator of G-protein signaling Z1, Regulator of Gz-selective protein signaling 1, G(z)GAP, Gz-GAP