RGS6
Domain
The RGS domain interacts avidly with Galpha and mediates the acceleration of Galpha-mediated GTP hydrolysis.
Function
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509).
Cellular localization
- Cytoplasm
- Cytoplasm
- Cytosol
- Membrane
- Peripheral membrane protein
- Nucleus
- Cell membrane
- Interaction with GNB5 mediates translocation to the nucleus.
Alternative names
Regulator of G-protein signaling 6, RGS6, S914