RHCG

Specifically expressed in fetal kidney.

Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4(+) ion with acidic residues of the pore entry followed by dissociation of NH4(+) into NH3 and H(+). As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4(+) (PubMed:11062476, PubMed:14761968, PubMed:15929723, PubMed:16477434, PubMed:16580862, PubMed:24077989). May act as a CO2 channel providing for renal acid secretion (PubMed:24077989).

N-glycosylated.

Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.

Expressed in brain, testis, placenta, pancreas, esophagus and prostate. Expressed in squamous epithelial tissues (at protein level). Expressed in kidney.

• Cell membrane
• Multi-pass membrane protein
• Apical cell membrane
• Multi-pass membrane protein
• Also detected at the basolateral membrane and in subapical vesicles.

C15orf6, CDRC2, PDRC2, RHGK, RHCG, Ammonium transporter Rh type C, Rh glycoprotein kidney, Rhesus blood group family type C glycoprotein, Tumor-related protein DRC2, Rh family type C glycoprotein, Rh type C glycoprotein

• entrezGene:51458
• omim:605381
• swissprot:Q9UBD6

Proteins

Oncology

53179Da