RHCG
Developmental stage
Specifically expressed in fetal kidney.
Function
Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4(+) ion with acidic residues of the pore entry followed by dissociation of NH4(+) into NH3 and H(+). As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4(+) (PubMed:11062476, PubMed:14761968, PubMed:15929723, PubMed:16477434, PubMed:16580862, PubMed:24077989). May act as a CO2 channel providing for renal acid secretion (PubMed:24077989).
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
Tissue Specificity
Expressed in brain, testis, placenta, pancreas, esophagus and prostate. Expressed in squamous epithelial tissues (at protein level). Expressed in kidney.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Apical cell membrane
- Multi-pass membrane protein
- Also detected at the basolateral membrane and in subapical vesicles.
Alternative names
C15orf6, CDRC2, PDRC2, RHGK, RHCG, Ammonium transporter Rh type C, Rh glycoprotein kidney, Rhesus blood group family type C glycoprotein, Tumor-related protein DRC2, Rh family type C glycoprotein, Rh type C glycoprotein