RHD
Function
May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
Involvement in disease
Hemolytic disease of fetus and newborn, RH-induced
HDFNRH
A disease that occurs in pregnancies in which mothers who lack the D antigen (RhD) of the Rh blood group have been exposed to the RhD-positive red cells of the fetus. The resulting maternal autoantibodies cross the placenta and destroy fetal red cells.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Palmitoylated.
Sequence Similarities
Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
Tissue Specificity
Restricted to tissues or cell lines expressing erythroid characters.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
CD240D, Blood group Rh(D) polypeptide, RHXIII, Rh polypeptide 2, Rhesus D antigen, RhPII, RHD