Rho GTPase-activating protein 9
Domain
A region including the PH domain and partially overlapping with the Rho-GAP domain mediates interaction with phosphoinositides.
Function
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate.
Tissue Specificity
Predominantly expressed in peripheral blood leukocytes, spleen, and thymus.
Alternative names
Rho GTPase-activating protein 9, Rho-type GTPase-activating protein 9, ARHGAP9