RHOD
Function
Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.
Sequence Similarities
Belongs to the small GTPase superfamily. Rho family.
Tissue Specificity
Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues.
Cellular localization
- Cell membrane
- Lipid-anchor
- Cytoplasmic side
- Early endosome
- Colocalizes with RAB5 to early endosomes (By similarity).
Alternative names
ARHD, RHOD, Rho-related GTP-binding protein RhoD, Rho-related protein HP1, RhoHP1