RHOF
Function
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.
Sequence Similarities
Belongs to the small GTPase superfamily. Rho family.
Cellular localization
- Cell membrane
- Lipid-anchor
- Cytoplasmic side
- Cytoplasm
- Cytoskeleton
Alternative names
ARHF, RIF, RHOF, Rho-related GTP-binding protein RhoF, Rho family GTPase Rif, Rho in filopodia