RHOQ
Function
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.
Post-translational modifications
May be post-translationally modified by both palmitoylation and polyisoprenylation.
Sequence Similarities
Belongs to the small GTPase superfamily. Rho family.
Cellular localization
- Cytoplasm
- Cell membrane
- Lipid-anchor
Alternative names
ARHQ, RASL7A, TC10, RHOQ, Rho-related GTP-binding protein RhoQ, Ras-like protein TC10, Ras-like protein family member 7A