RHOT1

Function

Mitochondrial GTPase involved in mitochondrial trafficking (PubMed:12482879, PubMed:16630562, PubMed:22396657). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:12482879, PubMed:16630562, PubMed:22396657).

Post-translational modifications

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy (PubMed:22396657, PubMed:24896179). Deubiquitinated by USP30 (PubMed:24896179).

Sequence similarities

Belongs to the mitochondrial Rho GTPase family.

Tissue specificity

Ubiquitously expressed. Expressed at high level in heart and skeletal muscle.

Cellular localization

• Mitochondrion outer membrane
• Single-pass type IV membrane protein
• Colocalizes with MGARP and RHOT2 at the mitochondria.

Alternative names

• Mitochondrial Rho GTPase 1
• MIRO-1
• hMiro-1
• Rac-GTP-binding protein-like protein
• Ras homolog gene family member T1
• RHOT1
• ARHT1

Database links

• entrezGene:55288
• omim:613888
• swissprot:Q8IXI2

Target type

Proteins

Molecular weight

70784Da