RHOT1
Function
Mitochondrial GTPase involved in mitochondrial trafficking (PubMed:12482879, PubMed:16630562, PubMed:22396657). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:12482879, PubMed:16630562, PubMed:22396657). Promotes mitochondrial fission during high calcium conditions (PubMed:27716788).
Post-translational modifications
Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy (PubMed:22396657, PubMed:24896179). Deubiquitinated by USP30 (PubMed:24896179).
Sequence Similarities
Belongs to the mitochondrial Rho GTPase family.
Tissue Specificity
Ubiquitously expressed. Expressed at high level in heart and skeletal muscle.
Cellular localization
- Mitochondrion outer membrane
- Single-pass type IV membrane protein
- Colocalizes with MGARP and RHOT2 at the mitochondria.
Alternative names
ARHT1, RHOT1, Mitochondrial Rho GTPase 1, MIRO-1, hMiro-1, Rac-GTP-binding protein-like protein, Ras homolog gene family member T1