RHOT2

Function

Mitochondrial GTPase involved in mitochondrial trafficking (PubMed:16630562, PubMed:22396657). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:22396657).

Post-translational modifications

Ubiquitinated by PRKN in a PINK1-dependent manner, leading to its degradation.

Sequence similarities

Belongs to the mitochondrial Rho GTPase family.

Tissue specificity

Ubiquitously expressed. Highly expressed in heart, liver, skeletal muscle, kidney and pancreas.

Cellular localization

• Mitochondrion outer membrane
• Single-pass type IV membrane protein
• Colocalizes with MGARP and RHOT2 at the mitochondria.

Alternative names

• Mitochondrial Rho GTPase 2
• MIRO-2
• hMiro-2
• Ras homolog gene family member T2
• C16orf39
• ARHT2
• RHOT2

Database links

• entrezGene:89941
• omim:613889
• swissprot:Q8IXI1

Target type

Proteins

Molecular weight

68118Da