RHOT2

Mitochondrial GTPase involved in mitochondrial trafficking (PubMed:16630562, PubMed:22396657). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:22396657).

Ubiquitinated by PRKN in a PINK1-dependent manner, leading to its degradation.

Belongs to the mitochondrial Rho GTPase family.

Ubiquitously expressed. Highly expressed in heart, liver, skeletal muscle, kidney and pancreas.

• Mitochondrion outer membrane
• Single-pass type IV membrane protein
• Colocalizes with MGARP and RHOT2 at the mitochondria.

ARHT2, C16orf39, RHOT2, Mitochondrial Rho GTPase 2, MIRO-2, hMiro-2, Ras homolog gene family member T2

• entrezGene:89941
• omim:613889
• swissprot:Q8IXI1

Proteins

Neuroscience

68118Da