RIN3
Function
Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.
Sequence Similarities
Belongs to the RIN (Ras interaction/interference) family.
Tissue Specificity
Widely expressed.
Cellular localization
- Cytoplasm
- Cytoplasmic vesicle
- Early endosome
- Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles.
Alternative names
Ras and Rab interactor 3, Ras interaction/interference protein 3, RIN3