RLN2

Function

Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.

Sequence Similarities

Belongs to the insulin family.

Tissue Specificity

Isoform 1 is expressed in the ovary during pregnancy. Also expressed in placenta, decidua and prostate. Isoform 2 is relatively abundant in placenta. It is in much lower abundance in the prostate gland. Not detected in the ovary.

Cellular localization

• Secreted

Alternative names

Prorelaxin H2, RLN2

Database links

swissprot:P04090 entrezGene:6013 entrezGene:6019 swissprot:P04808 omim:179740 omim:179730