RMDN3
Domain
The transmembrane region is required for mitochondrial localization.
The FFAT motif is required for interaction with MOSPD2 (PubMed:29858488). The FFAT motif is involved in the interaction with VAPA and VAPB and its phosphorylation regulates these interactions (PubMed:33124732).
Function
Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.
Post-translational modifications
Phosphorylation at Thr-160 of the FFAT motif activates interaction with MOSPD2, VAPA and VAPB.
Sequence Similarities
Belongs to the RMDN family.
Tissue Specificity
Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system (at protein level). Widely expressed.
Cellular localization
- Mitochondrion outer membrane
- Single-pass membrane protein
- Cytoplasm
- Nucleus
- Cytoplasm
- Cytoskeleton
- Spindle
- Cytoplasm
- Cytoskeleton
- Spindle pole
- In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles.
Alternative names
FAM82A2, FAM82C, PTPIP51, hucep-10, UNQ3122/PRO10274, RMDN3, Regulator of microtubule dynamics protein 3, RMD-3, hRMD-3, Cerebral protein 10, Protein FAM82A2, Protein FAM82C, Protein tyrosine phosphatase-interacting protein 51, TCPTP-interacting protein 51