RMI1
Function
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
Sequence Similarities
Belongs to the RMI1 family.
Cellular localization
- Nucleus
- Forms foci in response to DNA damage.
Alternative names
C9orf76, RMI1, RecQ-mediated genome instability protein 1, BLM-associated protein of 75 kDa, FAAP75, BLAP75