RNASE2
Domain
The N-terminal region is necessary for mediating chemotactic activity.
Function
This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities.
Post-translational modifications
A particular signal processing and glycosylation pattern may differentiate the UpI2 RNase, found specifically in pregnant women urine, from other nonsecretory RNases.
Sequence Similarities
Belongs to the pancreatic ribonuclease family.
Tissue Specificity
Liver, lung, spleen, leukocytes and body fluids.
Cellular localization
- Lysosome
- Cytoplasmic granule
- Matrix of eosinophil's large specific granule.
Alternative names
EDN, RNS2, RNASE2, Non-secretory ribonuclease, Eosinophil-derived neurotoxin, RNase UpI-2, Ribonuclease 2, Ribonuclease US, RNase 2