RNASE3
Function
Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.
Sequence Similarities
Belongs to the pancreatic ribonuclease family.
Cellular localization
- Secreted
- Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.
Alternative names
ECP, RNS3, RNASE3, Eosinophil cationic protein, Ribonuclease 3, RNase 3