RNASE6
Function
Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:27013146, PubMed:8836175). Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (PubMed:25075772, PubMed:27089320). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (PubMed:27089320). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (PubMed:27089320).
Sequence Similarities
Belongs to the pancreatic ribonuclease family.
Tissue Specificity
Highly expressed in spleen (at protein level) (PubMed:25075772, PubMed:8836175). Has little or no expression in healthy kidneys (at protein level) (PubMed:25075772). Detected in interstitial leukocytes in infected kidneys (at protein level) (PubMed:25075772). Expressed in ureter where it localizes to urothelial and submucosal leukocytes (at protein level) (PubMed:25075772). Strong expression in lung and thymus, and lower expression in heart, placenta, pancreas, liver, brain and skeletal muscle (PubMed:25075772, PubMed:8836175). Also expressed in monocytes and neutrophils (PubMed:8836175).
Cellular localization
- Secreted
- Lysosome
- Cytoplasmic granule
Alternative names
RNS6, RNASE6, Ribonuclease K6, RNase K6