RND1

Function

Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.

Sequence Similarities

Belongs to the small GTPase superfamily. Rho family.

Tissue Specificity

Mostly expressed in brain and liver.

Cellular localization

• Cell membrane
• Lipid-anchor
• Cytoplasmic side
• Cytoplasm
• Cytoskeleton

Alternative names

RHO6, RND1, Rho-related GTP-binding protein Rho6, Rho family GTPase 1, Rnd1

Database links

swissprot:Q92730 omim:609038 entrezGene:27289 genbank:NM_014470