RNF38
Function
Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme.
Pathway
Protein modification; protein ubiquitination.
Tissue Specificity
Widely expressed with highest levels in testis.
Cellular localization
- Nucleus
Alternative names
E3 ubiquitin-protein ligase RNF38, RING finger protein 38, RING-type E3 ubiquitin transferase RNF38, RNF38