RNF5

Function

Membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins (PubMed:11329381, PubMed:12861019, PubMed:16176924, PubMed:19269966, PubMed:19285439). May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4 (PubMed:11329381). Mediates ubiquitination of PXN/paxillin,thereby regulating cell motility and localization of PXN/paxillin (PubMed:12861019). Catalyzes ubiquitination of Salmonella type III secreted protein sopA (PubMed:16176924). Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N (PubMed:19269966). Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses (PubMed:19285439). Catalyzes ubiquitination and subsequent degradation of ATG4B, thereby inhibiting autophagy (PubMed:23093945).

Pathway

Protein modification; protein ubiquitination.

Sequence Similarities

Belongs to the RNF5 family.

Tissue Specificity

Widely expressed.

Cellular localization

• Cell membrane
• Multi-pass membrane protein
• Mitochondrion membrane
• Multi-pass membrane protein
• Endoplasmic reticulum membrane
• Multi-pass membrane protein
• Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles.

Alternative names

G16, NG2, RMA1, RNF5, E3 ubiquitin-protein ligase RNF5, RING finger protein 5, Ram1 homolog, HsRma1

Database links

swissprot:Q99942 omim:602677 swissprot:Q96GF1 entrezGene:6048 entrezGene:91445