Ror1

Developmental stage

At postnatal P0, expressed in heart, lung, liver, kidney, spleen and inner ear (PubMed:27162350). In the inner ear, at 14.5 dpc, detected in spiral ganglia, the cochlear epithelium and the vesitbule. At 17.5 dpc, expression increases in spiral ganglion neurons axon terminals adjacent to auditory hair cells. In the differentiating cochlear epithelium, the expression is intense in the stria vascularis. By P0, expression in the stria vascularis is weakened (PubMed:27162350).

Function

Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (By similarity). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (By similarity). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling (By similarity).

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.

Tissue Specificity

At postnatal P0, expressed in heart, lung, liver, kidney, spleen and inner ear.

Cellular localization

• Membrane
• Single-pass type I membrane protein
• Cell projection
• Axon

Alternative names

Ntrkr1, Ror1, Inactive tyrosine-protein kinase transmembrane receptor ROR1, mROR1

Database links

swissprot:Q9Z139 entrezGene:26563

Other research areas

• Immuno-oncology