RPS6KA2
Function
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
Post-translational modifications
Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1 (By similarity).
N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
Sequence Similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Tissue Specificity
Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
Cellular localization
- Nucleus
- Cytoplasm
Alternative names
MAPKAPK1C, RSK3, RPS6KA2, Ribosomal protein S6 kinase alpha-2, S6K-alpha-2, 90 kDa ribosomal protein S6 kinase 2, MAP kinase-activated protein kinase 1c, Ribosomal S6 kinase 3, pp90RSK3, p90-RSK 2, p90RSK2, MAPK-activated protein kinase 1c, MAPKAP kinase 1c, MAPKAPK-1c, RSK-3