RPS6KA6 phospho S232
Function
Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.
Post-translational modifications
Phosphorylated at Ser-232, Ser-372, and Ser-389 in serum-starved cells.
Sequence Similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Cellular localization
- Cytoplasm
- Cytosol
- Nucleus
- Predominantly cytosolic.
Alternative names
RSK4, RPS6KA6, Ribosomal protein S6 kinase alpha-6, S6K-alpha-6, 90 kDa ribosomal protein S6 kinase 6, Ribosomal S6 kinase 4, pp90RSK4, p90-RSK 6, p90RSK6, RSK-4