RRM2

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.

Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling. Phosphorylated on Thr-33 by CDK1 and CDK2; predominantly in G2 and M phase (PubMed:22632967).

Ubiquitinated by the SCF(CCNF) E3 ubiquitin-protein ligase complex; leading to its degradation by the proteasome.

Belongs to the ribonucleoside diphosphate reductase small chain family.

• Cytoplasm
• Nucleus
• Localized to the cytoplasm in S phase cells. May localize to the nucleus in G2 phase cells.

RR2, RRM2, Ribonucleoside-diphosphate reductase subunit M2, Ribonucleotide reductase small chain, Ribonucleotide reductase small subunit

• entrezGene:50484
• entrezGene:6241
• omim:180390
• omim:604712
• swissprot:P31350
• swissprot:Q7LG56

Proteins

Oncology

44878Da