RRN3
Function
Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC).
Post-translational modifications
Phosphorylation is required for participation in rDNA transcription (By similarity). Phosphorylated at Thr-200 by MAPK9/JNK2, which abrogates initiation complex formation.
Sequence Similarities
Belongs to the RRN3 family.
Cellular localization
- Nucleus
- Nucleolus
Alternative names
TIFIA, RRN3, RNA polymerase I-specific transcription initiation factor RRN3, Transcription initiation factor IA, TIF-IA