rRNA N6-adenosine-methyltransferase ZCCHC4

The regulatory loop blocks the catalytic center by bridging the methyltransferase domain and the C-terminal CCHC-type zinc finger, resulting in an autoinhibitory conformation.

rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA (PubMed:30531910, PubMed:31328227, PubMed:31695039, PubMed:31799605). N6-methylation of adenine(4220) in 28S rRNA is required for translation (PubMed:30531910, PubMed:31799605).

Belongs to the ZCCHC4 family.

• Nucleus
• Nucleolus
• Cytoplasm
• Accumulates in the nucleolus, where ribosome biogenesis takes place.

rRNA N(6)-adenosine-methyltransferase ZCCHC4, Zinc finger CCHC domain-containing protein 4, ZCCHC4

• entrezGene:29063
• omim:611792
• swissprot:Q9H5U6

Proteins

Oncology

59010Da