RRP1B
Developmental stage
During the cell cycle, expression peaks at the G1/S transition.
Function
Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015).
(Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA.
Post-translational modifications
Citrullinated by PADI4.
Sequence Similarities
Belongs to the RRP1 family.
Cellular localization
- Nucleus
- Nucleolus
- Nucleus
- Nucleoplasm
- Chromosome
- Predominantly located in the nucleolus with a small amount found in the nucleoplasm (PubMed:20926688). Associates with the perichromatin region during metaphase and with cytoplasmic foci during telophase before reaccumulation in the nucleolus during G2 (PubMed:20926688). Associates with heterochromatin and euchromatin (PubMed:19710015).
- Nucleus
- Nucleoplasm
- (Microbial infection) Following infection by influenza A virus, partially translocates from the nucleolus to the nucleoplasm.
Alternative names
KIAA0179, RRP1B, Ribosomal RNA processing protein 1 homolog B, RRP1-like protein B