RSF1

Function

Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex (PubMed:12972596). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11944984, PubMed:11788598).

Tissue specificity

Ubiquitously expressed.

Cellular localization

• Nucleus

Alternative names

• Remodeling and spacing factor 1
• Rsf-1
• HBV pX-associated protein 8
• Hepatitis B virus X-associated protein
• p325 subunit of RSF chromatin-remodeling complex
• RSF1
• HBXAP
• XAP8

Database links

• entrezGene:51773
• omim:608522
• swissprot:Q96T23

Target type

Proteins

Molecular weight

163821Da