RTCB
Function
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
Sequence Similarities
Belongs to the RtcB family.
Cellular localization
- Nucleus
- Cytoplasm
- Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low.
Alternative names
C22orf28, HSPC117, RTCB, RNA-splicing ligase RtcB homolog, 3'-phosphate/5'-hydroxy nucleic acid ligase