RTRAF
Function
RNA-binding protein involved in modulation of mRNA transcription by Polymerase II (PubMed:16950395). Component of the tRNA-splicing ligase complex and is required for tRNA ligation (PubMed:24870230). May be required for RNA transport (PubMed:24608264).
(Microbial infection) In case of infection by influenza virus A (IVA), is involved in viral replication (PubMed:21900157).
Sequence Similarities
Belongs to the RTRAF family.
Tissue Specificity
Widely expressed. Expressed at high level in heart and skeletal muscle. Expressed at intermediate level in liver, pancreas, fetal brain and fetal lung. Weakly expressed in adult brain, adult lung, placenta, fetal liver and fetal kidney. Overexpressed in many brain tumors.
Cellular localization
- Nucleus
- Cytoplasm
- Cytosol
- Cytoplasm
- Perinuclear region
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- May localize at the centrosome during mitosis (PubMed:15147888). Shuttles between the cytosol and the nucleus: enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264).
- Nucleus
- Cytoplasm
- (Microbial infection) Following influenza A virus (IAV) infection, included in influenza A virions via its association with packaged viral ribonucleoproteins (vRNP) in the nucleus and cytoplasm (PubMed:21900157, PubMed:26864902).
Alternative names
C14orf166, CGI-99, RTRAF, CLE7 homolog, CLE, hCLE