RUFY3

Function

Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (PubMed:25766321). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity). Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner (PubMed:25766321).

Post-translational modifications

Phosphorylated by PAK1 (PubMed:25766321). Isoform 1 is partially phosphorylated (By similarity).

Tissue Specificity

Overexpressed in gastric cancer cells and tissues (at protein level) (PubMed:25766321).

Cellular localization

• Cytoplasm
• Endomembrane system
• Cell projection
• Invadopodium
• Perikaryon
• Cell projection
• Cell projection
• Growth cone
• Cell projection
• Filopodium
• Cell projection
• Lamellipodium
• Colocalizes with PAK1, F-actin, myosins and integrins in invadopodia at the cell periphery (PubMed:25766321). Colocalized with Ras-related Rab-5 proteins in cytoplasmic vesicles (PubMed:20376209). Accumulates in axon growth cones in a F-actin-dependent manner (By similarity). Colocalized with FSCN1 and F-actin at filipodia and lamellipodia of axonal growth cones (By similarity). Colocalized with DBN1 and F-actin at transitional domain of the axonal growth cone (By similarity).

Alternative names

KIAA0871, RUFY3, Protein RUFY3, RUN and FYVE domain-containing protein 3, Rap2-interacting protein x, Single axon-regulated protein, RIPx, Singar

Database links

swissprot:Q7L099 entrezGene:22902 genbank:NM_014961 omim:611194