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RXFP3

Function

Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Tissue specificity

Expressed predominantly in brain regions. Highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level in cerebellum. In peripheral tissues, relatively high levels in adrenal glands, low levels in pancreas, salivary gland, placenta, mammary gland and testis.

Cellular localization

  • Cell membrane
  • Multi-pass membrane protein

Alternative names

  • Relaxin-3 receptor 1
  • RLN3 receptor 1
  • G protein-coupled receptor SALPR
  • G-protein coupled receptor GPCR135
  • Relaxin family peptide receptor 3
  • Somatostatin- and angiotensin-like peptide receptor
  • SALPR
  • RXFP3
  • GPCR135
  • RLN3R1

Target type

Proteins

Molecular weight

51124Da