RXFP3

Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.

Belongs to the G-protein coupled receptor 1 family.

Expressed predominantly in brain regions. Highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level in cerebellum. In peripheral tissues, relatively high levels in adrenal glands, low levels in pancreas, salivary gland, placenta, mammary gland and testis.

• Cell membrane
• Multi-pass membrane protein

GPCR135, RLN3R1, SALPR, RXFP3, Relaxin-3 receptor 1, RLN3 receptor 1, G protein-coupled receptor SALPR, G-protein coupled receptor GPCR135, Relaxin family peptide receptor 3, Somatostatin- and angiotensin-like peptide receptor

• entrezGene:51289
• omim:609445
• swissprot:Q9NSD7

Proteins

Neuroscience

51124Da