RXFP3
Function
Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Expressed predominantly in brain regions. Highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level in cerebellum. In peripheral tissues, relatively high levels in adrenal glands, low levels in pancreas, salivary gland, placenta, mammary gland and testis.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
GPCR135, RLN3R1, SALPR, RXFP3, Relaxin-3 receptor 1, RLN3 receptor 1, G protein-coupled receptor SALPR, G-protein coupled receptor GPCR135, Relaxin family peptide receptor 3, Somatostatin- and angiotensin-like peptide receptor