Retinoid X Receptor beta/RXRB

Domain

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).

Sequence similarities

Belongs to the nuclear hormone receptor family. NR2 subfamily.

Tissue specificity

Expressed in aortic endothelial cells (at protein level) (PubMed:28167758). Expressed in monocytes (PubMed:26463675). Expressed in a variety of tumor cell lines.

Cellular localization

• Nucleus
• Cytoplasm

Alternative names

• NR2B2
• RXRB
• NR2B2
• Retinoic acid receptor RXR-beta
• Nuclear receptor subfamily 2 group B member 2
• Retinoid X receptor beta

Database links

• entrezGene:6257
• omim:180246
• swissprot:P28702

Target type

Proteins

Primary research area

Oncology

Molecular weight

56922Da