RXRG
Domain
Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).
Post-translational modifications
Acetylated by EP300.
Sequence Similarities
Belongs to the nuclear hormone receptor family. NR2 subfamily.
Tissue Specificity
Expressed in aortic endothelial cells (at protein level).
Cellular localization
- Nucleus
- Cytoplasm
Alternative names
NR2B3, RXRG, Retinoic acid receptor RXR-gamma, Nuclear receptor subfamily 2 group B member 3, Retinoid X receptor gamma