S100A14
Function
Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium.
Sequence Similarities
Belongs to the S-100 family.
Tissue Specificity
Expressed at highest levels in colon and at moderate levels in thymus, kidney, liver, small intestine, and lung. Low expression in heart and no expression is seen in brain, skeletal muscle, spleen, placenta and peripheral blood leukocytes.
Cellular localization
- Cytoplasm
Alternative names
S100A15, S100A14, Protein S100-A14, S100 calcium-binding protein A14, S114