S100A3
Function
Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation.
Post-translational modifications
More than half of the arginine residues undergo citrullination by PAD1 and PAD2. Arg-51 is specifically citrullinated by PAD3 and promotes tetramerization.
Sequence Similarities
Belongs to the S-100 family.
Tissue Specificity
Skin specific, specifically expressed at the inner endocuticle of hair fibers.
Cellular localization
- Cytoplasm
Alternative names
S100E, S100A3, Protein S100-A3, Protein S-100E, S100 calcium-binding protein A3