S100P
Function
May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).
Sequence Similarities
Belongs to the S-100 family.
Tissue Specificity
Detected in all of the tissues except brain, testis and small intestine, expression level is higher in placenta, heart, lung, skeletal muscle, spleen and leukocyte. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias.
Cellular localization
- Nucleus
- Cytoplasm
- Cell projection
- Microvillus membrane
- Colocalizes with S100PBP in the nucleus. Colocolizes with EZR in the microvilli in a calcium-dependent manner.
Alternative names
S100E, S100P, Protein S100-P, Migration-inducing gene 9 protein, Protein S100-E, S100 calcium-binding protein P, MIG9