SAA1
GeneName
SAA1
Summary
SAA1, also known as serum amyloid A or SAA, is a 14 kDa acute-phase protein primarily produced by the liver. It is secreted into the extracellular region and is found in various forms, including high-density lipoprotein particles and extracellular exosomes. SAA1 plays a role in the acute-phase response to inflammation and is involved in several biological processes such as lymphocyte and macrophage chemotaxis, negative regulation of inflammatory responses, and platelet activation. Its functions are mediated through interactions with G protein-coupled receptors and heparin, contributing to cell adhesion and cytokine production.
Importance
SAA1 is relevant to: - The study of inflammatory diseases due to its role in the acute-phase response and regulation of inflammation - Immune response mechanisms, particularly in lymphocyte and neutrophil chemotaxis - Cardiovascular health, as it is associated with high-density lipoprotein and may influence lipid metabolism - Understanding amyloidosis, as abnormal accumulation of SAA can lead to amyloid fibril formation and related pathologies
Top Products
For researchers investigating SAA1, we highly recommend the Anti-SAA1 + SAA2 antibody [EPR19235] (ab199030). This top-selling recombinant antibody has been validated for use in Western blotting (WB), immunohistochemistry (IHC), and immunoprecipitation (IP), making it a versatile tool for various experimental needs. With 22 citations, it demonstrates a solid reputation within the research community, reflecting its reliability and effectiveness in detecting SAA1 and SAA2. This antibody is an excellent choice for those seeking consistent and robust results in their studies. The Anti-Serum Amyloid A antibody ELISA Kit (ab190801) is an excellent option for researchers looking to measure SAA1 levels in their samples.
Abcam Product Citation Summary
The use of the Abcam antibody ab157723 in this study highlights its application in measuring SAA1 levels in serum, specifically in male C57BL/6 mice subjected to different dietary conditions. This suggests a potential role of SAA1 in dietary response or metabolic changes.
Abcam Product Citation Table
Function
Major acute phase protein.
Involvement in disease
Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.
Elevated serum SAA1 protein levels may be associated with lung cancer.
Post-translational modifications
This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.
Sequence Similarities
Belongs to the SAA family.
Tissue Specificity
Expressed by the liver; secreted in plasma (at protein level).
Cellular localization
- Secreted
Alternative names
Serum amyloid A-1 protein, SAA, SAA1
Database links
swissprot:P0DJI8 omim:104750 omim:104751 swissprot:P0DJI9 swissprot:P02735 entrezGene:6288 entrezGene:6289 entrezGene:694827