SAA1
Function
Major acute phase protein.
Involvement in disease
Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.
Elevated serum SAA1 protein levels may be associated with lung cancer.
Post-translational modifications
This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.
Sequence Similarities
Belongs to the SAA family.
Tissue Specificity
Expressed by the liver; secreted in plasma (at protein level).
Cellular localization
- Secreted
Alternative names
Serum amyloid A-1 protein, SAA, SAA1