SAA1
Function
Major acute phase reactant. Apolipoprotein of the HDL complex.
Involvement in disease
Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.
Post-translational modifications
This protein is the precursor of amyloid protein A, which is formed by the removal of residues from the C-terminal end.
Sequence Similarities
Belongs to the SAA family.
Tissue Specificity
Expressed by the liver; secreted in plasma.
Cellular localization
- Secreted
Alternative names
SAA, SAA1, Serum amyloid A protein