SAE1
Function
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Pathway
Protein modification; protein sumoylation.
Sequence Similarities
Belongs to the ubiquitin-activating E1 family.
Tissue Specificity
Expression level increases during S phase and drops in G2 phase (at protein level).
Cellular localization
- Nucleus
Alternative names
AOS1, SUA1, UBLE1A, SAE1, SUMO-activating enzyme subunit 1, Ubiquitin-like 1-activating enzyme E1A