SAMD8
Domain
The SAM domain is required to retain SMAD8 in the endoplasmic reticulum.
Function
Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.
Sequence Similarities
Belongs to the sphingomyelin synthase family.
Cellular localization
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
Alternative names
Sphingomyelin synthase-related protein 1, SMSr, Ceramide phosphoethanolamine synthase, Sterile alpha motif domain-containing protein 8, CPE synthase, SAM domain-containing protein 8, SAMD8